In a healthy volunteer crossover study n 10 , coadministration of a single 20 mg dose of simvastatin at the end of a 14-day regimen with 120 mg bid diltiazem sr resulted in a 5-fold increase in mean simvastatin auc versus simvastatin alone….

Maraviroc is a cyp3a p-glycoprotein p-gp substrate and diltiazem is a cyp3a4 p-gp inhibitor….