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In a single-dose interaction study in NIDDM subjectsdecreases in glyburide AUC and Cmax were observedbut were highly variableThe single-dose nature of this study and the lack of correlation between glyburide blood levels and pharmacodynamic effectsmakes the clinical significance of this interaction uncertainCoadministration of glyburide and metformin did not result in any changes in either metformin pharmacokinetics or pharmacodynamics.
All sulfonylureas including MICRONASE are capable of producing severe hypoglycemiaProper patient selection and dosage and instructions are important to avoid hypoglycemic episodesRenal or hepatic similar paxil. insufficiency may cause elevated drug levels of glyburide and the latter may also diminish gluconeogenic capacityboth of which increase the risk of serious hypoglycemic reactionsElderlydebilitated or malnourished patientsand those with adrenal or pituitary insufficiencyare particularly susceptible to the hypoglycemic action of glucoselowering drugsHypoglycemia may be difficult to recognize in the elderly and in people who are taking betaadrenergic blocking drugsHypoglycemia is more likely to occur when caloric intake is deficientafter severe or prolonged exercisewhen alcohol is ingestedor when more than one glucose lowering drug is usedThe risk of hypoglycemia may be increased with combination therapy.
Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed dose.
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