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There have been post marketing reports of myocardial infarction including fatal casesCausality assessment was difficult in the majority of these cases because of serious pre-existing cardiac disease and plausible alternative causes.
Liquid products or dissolving tablets may contain sugar and/or aspartameLiquid products may also contain alcoholCaution is advised if you have diabetesliver diseasephenylketonuriaPKUor any other condition that requires you to limit/avoid these substances in your dietAsk your doctor or pharmacist about using this product safely.
No paediatric studies have been performedThe safety and efficacy of Clozaril in children and adolescents under the age of 16 years have not yet been establishedIt should not be used in this group until further data become available.
Undesirable alterations in lipids have been observed in patients treated with atypical antipsychoticsincluding ClozarilClinical monitoringincluding baseline and periodic follow-up lipid evaluations in patients using clozapineis recommended.
Immediate discontinuation of Clozaril is mandatory if either the WBC count is less than 3000/mm 33.0×10 9lor the ANC is less than 1500/mm 31.5×10 9lat any time during Clozaril treatmentPatients in whom Clozaril has been discontinued as a result of either WBC or ANC deficiencies must not be re-exposed to Clozaril.
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