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The results of a two-yearrandomizedplacebo-controlleddouble-blinddose-ranging study have shown that treatment with 0.5 mg estradiol daily for 23 daysof a 28 day cycleprevents vertebral bone mass loss in postmenopausal womenWhen estrogen therapy is discontinuedbone mass declines at a rate comparable to the immediate postmenopausal periodThere is no evidence that estrogen replacement therapy restores bone mass to premenopausal levels.
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