Triamterene is primarily metabolized to the sulfate conjugate of hydroxytriamterene….

, amiloride, digoxin, morphine, procainamide, quinidine, quinine, ranitidine, triamterene, trimethoprim, or vancomycin that are eliminated by renal tubular secretion theoretically have the potential for interaction with amaryl-mp metformin by competing for common renal tubular transport systems….