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As with levodopaperiodic evaluations of hepatichematopoieticcardiovascularand renal function are recommended during extended therapy.
NMS is an uncommon but life-threatening syndrome characterized by fever or hyperthermiaNeurological findingsincluding muscle rigidityinvoluntary movementsaltered consciousnessmental status changesother disturbancessuch as autonomic dysfunctiontachycardiatachypneasweatinghyperor hypotensionlaboratory findingssuch as creatine phosphokinase elevationleukocytosismyoglobinuriaand increased serum myoglobin have been reported.
Management of acute overdosage with SINEMET is the same as management of acute overdosage with levodopaPyridoxine is not effective in reversing the actions of SINEMET.
If you have not told your doctor about any of the abovetell them before you take any SINEMET.
In clinical pharmacologic studiessimultaneous administration of carbidopa and levodopa produced greater urinary excretion of levodopa in proportion to the excretion of dopamine than administration of the two drugs at separate times.
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