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The mean half-life of vero-danazol in healthy males is 9.

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In the case of acute overdosageconsideration should be given to reducing the absorption of the drug with activated charcoaland the patient should be kept under observation in case of any delayed reactions.

Use of Danazol in pregnancy is contraindicatedA sensitive teste.gbeta subunit test if availablecapable of determining early pregnancy is recommended immediately prior to start of therapyAdditionally a non-hormonal method of contraception should be used during therapyIf a patient becomes pregnant while taking Danazoladministration of the drug should be discontinued and the patient should be apprised of the potential risk to the fetusExposure to Danazol in utero may result in androgenic effects on the female fetusreports of clitoral hypertrophylabial fusionurogenital sinus defectvaginal atresiaand ambiguous genitalia have been receivedSee PRECAUTIONSPregnancyTeratogenic Effects

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Severe heart diseasea history of stroke or blood clotsevere kidney diseasesevere liver diseasea hormone-related cancer such as breast or uterine cancerporphyriaa genetic enzyme disorder that causes symptoms affecting the skin or nervous systemabnormal vaginal bleeding that has not been checked by a doctoror if you are pregnant or breast-feeding.

AGenerally acceptableControlled studies in pregnant women show no evidence of fetal risk.

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