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The pigmentation change is due to increased melanin content in the melanocytes rather than to an increase in the number of melanocytesAfter discontinuation of latanoprostpigmentation of the iris is likely to be permanentwhile pigmentation of the periorbital tissue and eyelash changes have been reported to be reversible in some patientsPatients who receive treatment should be informed of the possibility of increased pigmentationBeyond 5 years the effects of increased pigmentation are not knownsee Clinical Studies
The following reactions have been identified during postmarketing use of XALATAN in clinical practiceBecause they are reported voluntarily from a population of unknown sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposureThe reactionswhich have been chosen for inclusion due to either their seriousnessfrequency of reportingpossible causal connection to XALATANor a combination of these factorsinclude:
There have been reports of bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic productsThese containers had been inadvertently procialis. contaminated by patients whoin most caseshad a concurrent corneal disease or a disruption of the ocular epithelial surfacesee PATIENT INFORMATION
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