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Acetaminophen; dextromethorphan; phenylephrine major agents which induce the hepatic isoenzyme cyp2e1, such as isoniazid, may potentially increase the risk for acetaminophen-induced hepatotoxicity via generation of a greater percentage of acetaminophen s hepatotoxic metabolites.
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Isoniazid is an antibioticIt prevents tuberculous bacteria from multiplying in the body.
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the ser315thr mutation results in an enzyme without the ability to activate isoniazid, but retains approximately 50 of its catalase-peroxidase activity 18 .