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Store zestril at room temperature away from moisture and heat.
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Keep this leafletYou may need to read it againIf you have any further questionsask your doctor or pharmacistThis medicine has been prescribed for you onlyDo not pass it on to othersIt may harm themeven if their signs of illness are the same as yoursIf you get any side effectstalk to your doctor or pharmacistThis includes any possible side effects not listed in this leafletSee section 4.
Preclinical data reveal no special hazard for humans based on conventional studies of general pharmacologyrepeated dose toxicitygenotoxicityand carcinogenic potentialAngiotensin-converting enzyme inhibitorsas a classhave been shown to induce adverse effects on the late foetal developmentresulting in foetal death and congenital effectsin particular affecting the skullFoetotoxicityintrauterine growth retardation and patent ductus arteriosus have also been reportedThese developmental anomalies are thought to be partly due to a direct action of ACE inhibitors on the foetal renin-angiotensin system and partly due to ischaemia resulting from maternal hypotension and decreases in foetal-placental blood flow and oxygen/nutrients delivery to the foetus.
If you are not sure if any of these apply to youtalk to your doctor or pharmacist before taking Zestril.
Swallow the tablet with a drink of waterTry to take your tablets at the same time each dayIt does not matter if you take Zestril before or after foodKeep taking Zestril for as long as your doctor tells you toit is a long term treatmentIt is important to keep taking Zestril every day.
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dose adjustment of zestril is required in patients undergoing hemodialysis or whose creatinine clearance is 30 ml min.