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Treatment with metoclopramide can cause tardive dyskinesiaa serious movement disorder that is often irreversibleThe risk of developing tardive dyskinesia increases with duration of treatment and total cumulative dose.

Safety and effectiveness in pediatric patients have not been establishedsee OVERDOSE

Treatment with metoclopramide can cause tardive dyskinesiaa serious movement disorder that is often irreversibleThe risk of developing tardive dyskinesia increases with duration of treatment and total cumulative dose.

The initial two doses should be 2 mg/kg if highly emetogenic drugs such as cisplatin or dacarbazine are used alone or in combinationFor less emetogenic regimens1 mg/kg per dose may be adequate.

Metoclopramide is contraindicated in patients with known sensitivity or intolerance to the drugMetoclopramide should not be used in epileptics or patients receiving other drugs which are likely to cause extrapyramidal reactionssince the frequency and severity of seizures or extrapyramidal reactions may be increased.

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