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Hemorrhagesee BOX WARNINGWARNINGS AND PRECAUTIONS and OVERDOSETissue Necrosissee WARNINGS AND PRECAUTIONSCalciphylaxissee WARNINGS AND PRECAUTIONSAcute Kidney Injurysee WARNINGS AND PRECAUTIONSSystemic Atheroemboli and Cholesterol Microembolisee WARNINGS AND PRECAUTIONSLimb IschemiaNecrosisand Gangrene in Patients with HIT and HITTSsee WARNINGS AND PRECAUTIONSOther Clinical Settings with Increased Riskssee WARNINGS antibusemedication. AND PRECAUTIONS
If you cut yourself and it’s largeapply constant pressure and get help immediatelyeither by phone or at the emergency roomCall your doctor if you have any symptoms of illness like vomitingdiarrheainfectionor feverIllness can change the way warfarin works.
If you receive Coumadin in a hospitalcall or visit your doctor 3 to 7 days after you leave the hospitalYour INR will need to be tested at that timeDo not miss any follow-up appointments.
No dosage adjustment is necessary for patients with renal failureMonitor INR more frequently in patients with compromised renal function to maintain INR within the therapeutic rangesee WARNINGS AND PRECAUTIONS and Use In Specific Populations
Coumadin has no direct effect on an established thrombusnor does it reverse ischemic tissue damageOnce a thrombus has occurredhoweverthe goals of anticoagulant treatment are to prevent further extension of the formed clot and to prevent secondary thromboembolic complications that may result in serious and possibly fatal sequelae.
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