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Be sure to mention the medications listed in the important warning section and any of the following acetaminophen tylenol, other products ; angiotensin-converting enzyme ace inhibitors such as benazepril lotensin, in lotrel , captopril, enalapril vasotec, in vaseretic , fosinopril, lisinopril in zestoretic , moexipril univasc, in uniretic ; perindopril aceon, in prestalia , quinapril accupril, in quinaretic , ramipril altace , and trandolapril mavik, in tarka ; angiotensin receptor blockers such as candesartan atacand, in atacand hct , eprosartan teveten , irbesartan avapro, in avalide , losartan cozaar, in hyzaar , olmesartan benicar, in azor, in benicar hct, in tribenzor , telmisartan micardis, in micardis hct, in twynsta , and valsartan in exforge hct ; certain antibiotics; beta blockers such as atenolol tenormin, in tenoretic , labetalol trandate , metoprolol lopressor, toprol xl, in dutoprol , nadolol corgard, in corzide , and propranolol hemangeol, inderal, innopran ; cyclosporine gengraf, neoral, sandimmune ; diuretics water pills ; lithium lithobid ; medications for seizures; and methotrexate otrexup, rasuvo, trexall .
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When gradually stopping this medicationit is recommended that you temporarily limit physical activity to decrease strain on the heartSeek immediate medical attention if you develop chest pain/tightness/pressurechest pain spreading to the jaw/neck/armunusual sweatingtrouble breathingor fast/irregular heartbeat.
A very serious allergic reaction to this drug is rareHoweverseek immediate medical attention if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.
This list is not complete and other drugs may interact with labetalolTell your doctor about all medications you useThis includes prescriptionover-the-countervitaminand herbal productsDo not start a new medication without telling your doctor.
Labetalol is only part of a complete program of treatment for hypertension that may also include dietexerciseand weight controlFollow your dietmedicationand exercise routines very closely if you are being treated for hypertension.
PharmacodynamicsThe capacity of labetalol HCl to block alpha receptors in man has been demonstrated by attenuation of the pressor effect of phenylephrine and by a significant reduction of the pressor response caused by immersing the hand in ice-cold watercold-pressor testLabetalol HCl’s beta 1receptor blockade in man was demonstrated by a small decrease in the resting heart rateattenuation of tachycardia produced by isoproterenol or exerciseand by attenuation of the reflex tachycardia to the hypotension produced by amyl nitriteBeta 2receptor blockade was demonstrated by inhibition of the isoproterenol-induced fall in diastolic blood pressureBoth the alphaand beta-blocking actions of orally administered labetalol HCl contribute to a decrease in blood pressure in hypertensive patientsLabetalol HCl consistentlyin dose-related fashionblunted increases in exercise-induced blood pressure and heart rateand in their double productThe pulmonary circulation during exercise was not affected by labetalol HCl dosing.
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do not skip doses or stop taking trandate without first talking to your doctor.