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Data collected from postmarketing use of REVIA show that most events usually occur early in the course of drug therapy and are transientIt is not always possible to distinguish these occurrences from those signs and symptoms that may result from a withdrawal syndromeEvents that have been reported include anorexiaastheniachest painfatigueheadachehot flushesmalaisechanges in blood pressureagitationdizzinesshyperkinesianauseavomitingtremorabdominal paindiarrheapalpitationsmyalgiaanxietyconfusioneuphoriahallucinationsinsomnianervousnesssomnolenceabnormal thinkingdyspnearashincreased sweatingvision abnormalitiesand idiopathic thrombocytopenic purpura.
Patients taking REVIA may not benefit from opioid containing medicinessuch as cough and cold preparationsantidiarrheal preparationsand opioid analgesicsIn an emergency situation when opioid analgesia must be administered to a patient receiving REVIAthe amount of opioid required may be greater than usualand the resulting respiratory depression may be deeper and more prolongedsee PRECAUTIONS
There is also the possibility that a patient who is treated with REVIA could overcome the opioid blockade effect of REVIAAlthough REVIA is a potent antagonistthe blockade produced by REVIA is surmountableThe plasma concentration of exogenous opioids attained immediately following their acute administration may be sufficient to overcome the competitive receptor blockadeThis poses a potential risk to individuals finasteride online store. who attempton their ownto overcome the blockade by administering large amounts of exogenous opioidsAny attempt by a patient to overcome the antagonism by taking opioids is especially dangerous and may lead to life-threatening opioid intoxication or fatal overdosePatients should be told of the serious consequences of trying to overcome the opioid blockadesee PATIENT INFORMATION
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