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It is not known whether ondansetron passes into breast milk or if it could harm a nursing babyDo not use this medication without telling your doctor if you are breast-feeding a baby.
Previous versions of the ondansetron labels included a warning about QT interval prolongationThe FDA added a new warning to avoid the use of ondansetron in patients with congenital long QT syndrome because these patients are at particular risk for developing Torsade.
The following adverse reactions have been identified during post-approval use of ondansetronBecause these reactions are reported voluntarily from a population of uncertain sizeit is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure.
Arrhythmiasincluding ventricular and supraventricular tachycardiapremature ventricular contractionsand atrial fibrillationbradycardiaelectrocardiographic alterationsincluding second-degree heart blockQT/QTc interval prolongationand ST segment depressionpalpitationsand syncopeRarely and predominantly with intravenous ondansetrontransient ECG changes including QT interval prolongation have been reported.
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