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Do not change your dose or stop protonix without talking to your doctor.

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A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathingsigns of kidney problemssuch as change in the amount of urine

Nauseavomitingabdominal paindry mouthand constipation were more commonly reported in patients given triple therapycompared to patients given quadruple therapy.

Acute interstitial nephritis has been observed in patients taking PPIs including Protonix I.VAcute interstitial nephritis may occur at any point during PPI therapy and is generally attributed to an idiopathic hypersensitivity reactionDiscontinue Protonix I.Vif acute interstitial nephritis developssee Contraindications4

The safety and effectiveness of Protonix I.Vhave not been established in pediatric patients.

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table 4 includes drugs with clinically important drug interactions and interaction with diagnostics when administered concomitantly with protonix and instructions for preventing or managing them.