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When coadministered with morphineon a chronic basisREVIA blocks the physical dependence to morphineheroin and other opioids.
There was limited evidence of a weak genotoxic effect of naltrexone in one gene mutation assay in a mammalian cell linein the Drosophila recessive lethal assayand in non-specific DNA repair tests with EcoliHoweverno evidence of genotoxic potential was observed in a range of other in vitro testsincluding assays for gene mutation in bacteriayeastor in a second mammalian cell linea chromosomal aberration assayand an assay for DNA damage in human cellsNaltrexone did not exhibit clastogenicity in an in vivo mouse micronucleus assay.
Naltrexone will help you avoid using drugs and alcoholbut it will not prevent or relieve the withdrawal symptoms that may occur when you stop using these substancesInsteadnaltrexone may cause or worsen withdrawal symptomsYou should not take naltrexone if you have recently stopped using opioid medications or opioid street drugs and are now experiencing withdrawal symptoms.
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