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Because of its inhibitory effect on fibroplasiamethylprednisolone may mask the signs of infection and enhance dissemination of the infecting organismHenceall animal patients receiving methylprednisolone should be watched for evidence of intercurrent infectionShould infection occurit must be brought under control by use of appropriate antibacterial measuresor administration of methylprednisolone should be discontinued.
Potentiated by CYP3A4 inhibitorsegketoconazolemacrolidescyclosporineestrogensAntagonized by CYP3A4 inducersegbarbituratesphenytoincarbamazepinerifampincholestyramineMay potentiate cyclosporineseizure riskMay antagonize oral anticoagulantsmonitorisoniazidIncreased risk of arrhythmias with digitalisMay need to adjust dose of antidiabetic agentsMonitor for hypokalemia with potassium-depleting drugsegamphotericin BdiureticsConcomitant neuromuscular blocking agentsincreased risk of myopathyWithdraw anticholinesterase agents at least 24hrs before initiating corticosteroid therapyAminoglutethimide may lead to loss of corticosteroid-induced adrenal suppressionIncreased GI effects with aspirinother NSAIDsCaution with aspirin in hypoprothrombinemiaMay suppress reactions to skin tests.
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