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Metformin associated lactic acidosis was characterized by elevated blood lactate levels, anion gap acidosis without evidence of ketonuria or ketonemia , an increased lactate pyruvate ratio; and metformin plasma levels generally 5 mcg ml see precautions .

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Metformin oral tablet comes in two formsimmediate-release and extended-releaseThe immediate-release tablet is available as the brand-name drug GlucophageThe extended-release tablet is available as the brand-name drugs Glucophage XRFortametand Glumetza

Using certain diabetes drugs with metformin can cause low blood sugar levelsIf you start taking metforminyour doctor may reduce your dosage of your other diabetes medicationsExamples of these drugs include:

Steroid tablets such as prednisolone water tablets such as furosemide medicines to treat heart problems and high blood pressure male and female hormones such as testosteroneoestrogen and progesterone other diabetes medicines.

If you miss a dose of metformintake the next dose at the usual timeDo not take a double dose to make up for a forgotten dose.

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