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Corticosteroids may mask some signs of infectionand new infections may appear during their useThere may be decreased resistance and inability to localize infection when corticosteroids are usedIf an infection occurs during fludrocortisone acetate therapyit should be promptly controlled by suitable antimicrobial therapy.
Psychic derangements may appear when corticosteroids areusedThese may range from euphoriainsomniamood swingspersonality changesand severe depression to frank psychotic manifestationsExisting emotional instability or psychotic tendencies may also be aggravated by corticosteroids.
Infants born of mothers who have received substantial doses of fludrocortisone acetate during pregnancy should be carefully observed for signs of hypoadrenalism.
Other adverse reactions that may occur following the administration of a corticosteroid are necrotizing angiitisthrombophlebitisaggravation or masking of infectionsinsomniasyncopal episodesand anaphylactoid reactions.
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