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As with other drugs primarily metabolised through cyp3a4, regular ingestion of grapefruit or its juice, should be avoided in connection with entocort cr capsules administration other juices such as orange juice or apple juice do not inhibit cyp3a4 .
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Budesonide is a substrate for CYP3A4Avoid use with CYP3A4 inhibitorsConcomitant oral administration of a strong CYP3A4 inhibitorketoconazolecaused an eight-fold increase of the systemic exposure to oral budesonideInhibitors of CYP3A4e.gketoconazoleitraconazoleritonavirindinavirsaquinavirerythromycinand cyclosporinecan increase systemic budesonide concentrationssee CLINICAL PHARMACOLOGY
Symptoms Of Steroid Withdrawal In Patients Transferred From Other Systemic Corticosteroids.
Take ENTOCORT EC capsules once daily in the morningSwallow ENTOCORT EC capsules wholeDo not chew or crushAvoid consumption of grapefruit juice for the duration of their ENTOCORT EC therapysee DRUG INTERACTIONS
Budesonide pharmacokinetics were dose-proportional following repeated administration in the dose range of 3 to 15 mgNo accumulation of budesonide was observed following repeated dosing.
A very serious allergic reaction to this drug is rareHoweverseek immediate medical attention if you notice any symptoms of a serious allergic reactionrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.
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