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Nonsteroidal anti-inflammatory drugsNSAIDscause an increased risk of serious cardiovascular thrombotic eventsincluding myocardial infarctionand strokewhich can be fatalThis risk may occur early in the treatment and may increase with duration of usesee WARNINGS AND PRECAUTIONSCELEBREX is contraindicated in the setting of coronary artery bypass graftCABGsurgerysee CONTRAINDICATIONS and WARNINGS AND PRECAUTIONS]
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Consider alternative management in patients who are poor CYP2C9 metabolizers.
Avoid the use of CELEBREX in patients with severe heart failure unless the benefits are expected to outweigh the risk of worsening heart failureIf CELEBREX is used in patients with severe heart failuremonitor patients for signs of worsening heart failure.
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