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Concomitant warfarin useCo-administration of ORBACTIVand warfarin may result in higher exposure of warfarinwhich may increase the risk of bleedingUse ORBACTIV in patients on chronic warfarin therapy only when the benefits can be expected to outweigh the risk of bleeding.
Nauseavomitingdiarrhealightheadednessdizzinessor a feeling of spinning may occurIf any of these effects last or get worsetell your doctor or pharmacist promptly.
MusculoskeletalArthralgiaarthritisbone discolorationmyalgiajoint stiffnessand joint swelling.
Although IH typically resolves after discontinuation of treatmentthe possibility for permanent visual loss existsIf visual disturbance occurs during treatmentprompt fluoxetinewithoutaprecription. ophthalmologic evaluation is warrantedSince intracranial pressure can remain elevated for weeks after drug cessation patients should be monitored until they stabilize.
Drug Rash with Eosinophilia and Systemic SymptomsDRESSincluding fatal cases have been reported with minocycline useIf this syndrome is recognizedthe drug should be discontinued immediately.
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