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$25.00s paperback9780295742182Add to Cart90.00x hardcover9780295742175Add to Cart PublishedSeptember 2017 Subject ListingWomen’sGenderand Sexuality StudiesScience and Technology StudiesNative American and Indigenous Studies Bibliographic information232 pp5 bandw illus6 x 9 inTerritorial rightsN/A in South Africa SeriesFeminist Technosciences Contents Native to the Kalahari DesertHoodia gordonii is a succulent plant known by generations of Indigenous San peoples to have a variety of usesto reduce hungerincrease energyand ease breastfeedingIn the global Northit is known as a natural appetite suppressanta former star of the booming diet industryIn Reinventing HoodiaLaura Foster explores how the plant was reinvented through patent ownershippharmaceutical researchthe self-determination efforts of Indigenous San peoplescontractual benefit sharingcommercial development as an herbal supplementand bioprospecting legislation.
Edited by Robert JLefkowitzHoward Hughes Medical InstituteDuke University Medical CenterDurhamNCand approved alli shortage orlistat. August 192014received for review December 292013)
The plant is rich in pregnane glycosides containing 6-deoxyand 2,6-dideoxy-sugarsTo dateP57AS3P57is the only biologically active constituent from Hgordonii that has been reported to have anorexigenic activity5There is no evidence of P57 binding to or altering activity of known receptors or proteinsbut intracerebroventricular injections of P57 in rats has been reported to increase ATP content in the hypothalamuswhich might represent a signal of satiety and suppress appetitive responses6Howevera recent study claimed that P57 was not detectable in the brain upon oral administration in micewhich makes the mechanisms of action of P57 and Hgordonii more elusive7The development and commercialization of Hgordonii and P57 have been problematic due to controversy about intellectual property rights and limited natural resourcesin addition to the lack of a clear mechanismresulting in the withdrawal of several major pharmaceutical companies from Hoodia projects3Since the isolation of P57more new glycosidesincluding Gordonoside A-L8have been disclosed in the literature although their bioactivities remain unclear.
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A chemical in hoodia called P57 is thought to decrease feelings of hungerBut it is not known if hoodia has this effect when used in people.
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