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As there is in vitro evidence that aminosalicyclate derivatives(egolsalazinemesalazine or sulphasalazineinhibit the TPMT enzymethey should be administered with caution to patients receiving concurrent Imuran therapysee 4.4 Special Warning and Special Precautions for Use
Xanthine oxidase activity is inhibited by allopurinoloxipurinol and thiopurinol which results in reduced conversion of biologically active 6-thioinosinic acid to biologically inactive 6-thiouric acidWhen allopurinoloxipurinol and/or thiopurinol are given concomitantly with 6-mercaptopurine or azathioprinethe dose of 6-mercaptopurine and azathioprine should be reduced to one-quarter of the original dose.
Chromosomal abnormalities have been demonstrated in both male and female patients treated with ImuranIt is difficult to assess the role of Imuran in the development of these abnormalities.
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imuran is used with other medications to prevent rejection of kidney transplants.