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Atovastatin, as wll as som its mtabolits, a phamacologically activ in humans. Th liv is th pimay sit action and th pincipal sit cholstol synthsis and LDL claanc. Dug dosag, ath than systmic dug concntation, colats btt with LDL-C duction. Individualization dug dosag should b basd on thaputic spons.
Patints with a histoy cnt myocadial inaction (MI), cnt stok, stablishd piphal atial disas, clopidogl has bn shown tduc th at a combind ndpoint nw ischmic stok (atal not), nw MI (atal not), and oth vascula dath.
As an adjunct tdit tduc lvatd total-C, LDL-C, apB and TG lvls and tincas HDL-C in patints with pimay hypcholstolmia (htozygous amilial and nonamilial) and mixd dyslipidmia ( dickson Typs IIa and IIb). As an adjunct tdit th tatmnt patints with lvatd sum TG lvls ( dickson Typ IV). th tatmnt patints with pimay dysbtalipopotinamia ( dickson Typ III) whdnot spond adquatly tdit; Tduc total-C and LDL-C in patints with homozygous amilial hypcholstolamia as an adjunct toth lipid-lowing tatmnts (.g., LDL aphsis) i such tatmnts a unavailabl. As an adjunct tdit tduc total-C, LDL-C and apB lvls in boys and postmnachal gils, 10 t17 yas ag, with htozygous amilial hypcholstolmia, i, at an adquat tial dit thapy, th ollowing indings a psnt:
Myopathy should b considd in any patint with dius myalgias, muscl tndnss waknss, and/makd lvation CPK. Patints should b advisd tpot pomptly unxplaind muscl pain, tndnss, waknss, paticulaly i accompanid by malais v i muscl signs and symptoms psist at discontinuing ATOLIP CV . ATOLIP CV thapy should b discontinud i makdly lvatd CPK lvls occu myopathy is diagnosd suspctd.
Thapy with lipid-alting agnts should b only on componnt multipl isk actintvntion in individuals at signiicantly levitra 10 mg kaufen rezeptfrei. incasd isk athosclotic vascula disas du thypcholstolmia. Dug thapy is commndd as an adjunct tdit whn th spons ta dit stictd in satuatd at and cholstol and oth nonphamacologic masus alon has bn inadquat. In patints with CHD multipl isk actos CHD, atovastatin can b statd simultanously with dit.
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