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Renal although no direct relationship of clindamycin to renal damage has been established, renal dysfunction as evidenced by azotemia, oliguria, and or proteinuria has been observed.
Information about Clindamycin.
Clindamycin dosage modification may not be necessary in patients with renal disease.
May increase risk of drug-resistant bacteria if prescribed in the absence of proven or strongly suspected bacterial infection.
HematopoieticTransient neutropenialeukopeniaand eosinophilia have been reportedReports of agranulocytosis and thrombocytopenia have been madeNo direct etiologic relationship to concurrent clindamycin therapy could be made in any of the foregoing.
Serum half-life of clindamycin is increased slightly in patients with markedly reduced renal functionHemodialysis and peritoneal dialysis are not effective in removing clindamycin from the serum.
Clindamycin dosage modification may not be necessary in patients with renal disease.
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