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NevirapineCo-administration of ritonavir does not lead to any clinically relevant change in nevirapine plasma levels.
Currently available data on pregnant women indicate no malformative or foetoneonatal toxicityTo date no other relevant epidemiological data are availableNo observable teratogenicity was detected in reproductive studies performed in pregnant rats and rabbitssee section 5.3There are no adequate and well-controlled studies in pregnant womenCaution should be exercised when prescribing nevirapine to pregnant womensee section 4.4As hepatotoxicity is more frequent in women with CD4 cell counts above 250 cells/mm 3 with detectable HIV-1 RNA in plasma50 or more copies/mlthese conditions should be taken in consideration on therapeutic decisionsee section 4.4There is indian tadalafil. not enough evidence to substantiate that the absence of an increased risk for toxicity seen in pre-treated women initiating nevirapine with an undetectable viral loadless than 50 copies/ml of HIV-1 in plasmaand CD4 cell counts above 250 cells/mm 3 also applies to pregnant womenAll the randomised studies addressing this issue specifically excluded pregnant womenand pregnant women were under-represented in cohort studies as well as in meta-analyses.
The absorption of nevirapine is not affected by foodantacids or medicinal products which are formulated with an alkaline buffering agent.
Interferons have no known effect on CYP 3A4 or 2B6No clinically relevant drug-drug interaction is expected.
The nevirapine twice daily regimen and the efavirenz regimen were not significantly differentp=0.091in terms of efficacy as measured by treatment failureor any component of treatment failure including virological failure.
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