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Unintentional overdose due to misadministration has been reported in infants and children with the use of Reglan syrupWhile there was no consistent pattern to the reports associated with these overdosesevents included seizuresextrapyramidal reactionsand lethargy.
Giving a promotility drug such as metoclopramide theoretically could put increased pressure on suture lines following a gut anastomosis or closureThis possibility should be considered and weighed when deciding whether to use metoclopramide or nasogastric suction in the prevention of postoperative nausea and vomiting.
Motor restlessnessakathisiamay consist of feelings of anxietyagitationjitterinessand insomniaas well as inability to sit stillpacingfoot tappingThese symptoms may disappear spontaneously or respond to a reduction in dosage.
Metoclopramide is contraindicated in patients with known sensitivity or intolerance to the drugMetoclopramide should not be used in epileptics or patients receiving other drugs which are likely to cause extrapyramidal reactionssince the frequency and severity of seizures or extrapyramidal reactions may be increased.
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