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A very serious allergic reaction to this drug is rareHoweverget medical help right away if you notice any symptoms of a serious allergic reactionincludingrashitching/swellingespecially of the face/tongue/throatsevere dizzinesstrouble breathing.
The Coxib and traditional NSAID TrialistsCollaboration meta-analysis of randomized controlled trials demonstrated an approximately two-fold increase in hospitalizations for heart failure in COX-2 selective-treated patients and nonselective NSAID-treated patients compared to placebo-treated patientsIn a Danish National Registry study of patients with heart failureNSAID use increased the risk of MIhospitalization for heart failureand death.
Mefenamic acid pharmacokinetics have not been investigated in subjects with renal insufficiencyGiven that mefenamic acidits metabolites and conjugates are primarily excreted by the kidneysthe potential exists for mefenamic acid metabolites to accumulatePonstel should not be administered to patients with pre-existing renal disease or in patients with significantly impaired renal functionsee WARNINGSRenal Toxicity and Hyperkalemia
Before taking mefenamic acidtell your doctor if you are taking any of the following drugs:
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