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Bupropion hydrochloride extended-release tablets xl should be used with caution in patients with renal impairment and a reduced frequency and or dose should be considered see clinical pharmacology and precautions .
Information about Bupropion.
Screen patients for bipolar disorder and monitor for these symptomsmay precipitate manichypomanic or mixed episodes in patients with bipolar disorder.
Take the missed dose as soon as you rememberSkip the missed dose if it is almost time for your next scheduled doseDo not take extra medicine to make up the missed dose.
Do not use bupropion within 14 days before or 14 days after you have used a MAO inhibitorsuch as isocarboxazidlinezolidmethylene blue injectionphenelzinerasagilineselegilineor tranylcypromine.
In short-term studiesantidepressants increased t suicidal thinking and behavior in childrenadolescentsand young adultsyounger than 24 yearstaking antidepressants for major depressive disorders and other psychiatric illnessesthis increase was not seen in patients older than 24 years Slight decrease in suicidal thinking was seen in adults older than 65 years In children and young adultsrisks must be weighed against the benefits of taking antidepressants Patients should be monitored closely for changes in behaviorclinical worseningand suicidal tendenciesthis should be done during initial 1-2 months of therapy and dosage adjustments The patient’s family should communicate any abrupt changes in behavior to the healthcare provider Worsening behavior and suicidal tendencies that are not part of the presenting symptoms may require discontinuation of therapythis drug is not approved for use in pediatric patients.
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treatment of depression sustained release the usual adult target dose for bupropion sustained release tablets is 300 mg day, given as 150 mg, twice daily.