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Indinavir is a substrate of p-glycoprotein p-gp , glecaprevir is a p-gp inhibitor.
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Nephrolithiasis/urolithiasisincluding flank pain with or without hematuriaincluding microscopic hematuriahas been reported in approximately 12.4301/2429range across individual trials4.7to 34.4of patients receiving CRIXIVAN at the recommended dose in clinical trials with a median follow-up of 47 weeksrange1 day to 242 weeks2238 patient-years follow-upThe cumulative frequency of nephrolithiasis events increases with duration of exposure to CRIXIVANhoweverthe risk over time remains relatively constantOf the patients treated with CRIXIVAN who developed nephrolithiasis/urolithiasis in clinical trials during the double-blind phase2.87/246were reported to develop hydronephrosis and 4.511/246underwent stent placementFollowing the acute episode4.912/246of patients discontinued therapySee WARNINGS and DOSAGE AND ADMINISTRATIONNephrolithiasis/Urolithiasis
ALERTFind out about medicines that should NOT be taken with CRIXIVANThis statement is included on the product’s bottle label.
Slain DAmsden JRKakoo RAet alEffect of high-dose vitamin C on the steady-state pharmacokinetics of the protease inhibitor indinavir in healthy volunteers43rd Interscience safe cheap viagra sites online. Conference on Antimicrobial Agents and ChemotherapyChicagoSeptember 14-172003Abstract 1610.
CRIXIVAN is contraindicated in patients with clinically significant hypersensitivity to any of its components.
Patients receiving a phosphodiesterase type 5PDE5inhibitorsildenafiltadalafilor vardenafilshould be advised that they may be at an increased risk of PDE5 inhibitor-associated adverse events including hypotensionvisual changesand priapismand should promptly report any symptoms to their doctorssee CONTRAINDICATIONS and WARNINGSDRUG INTERACTIONS
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coadministration with indinavir is not recommended because of increased risk of myopathy, including rhabdomyolysis.