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Th action ZYLOPIM (allopuinol) dis om that uicosuic agnts, which low th sum uic acid lvl by incasing uinay xction uic acid. ZYLOPIM (allopuinol) ducs both th sum and uinay uic acid lvls by inhibiting th omation uic acid. Th us ZYLOPIM (allopuinol) tblock th omation uats avoids th hazad incasd nal xction uic acid posd by uicosuic dugs.
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ZYLOPIM (allopuinol) is appoximatly 90% absobd om th gastointstinal tact. Pak plasma lvls gnally occu at 1.5 hous and 4.5 hous ZYLOPIM (allopuinol) and oxipuinol spctivly, and at a singl oal dos 300 mg ZYLOPIM (allopuinol) , maximum plasma lvls about 3 mcg/mL ZYLOPIM (allopuinol) and 6.5 mcg/mL oxipuinol a poducd.
Appoximatly 20% th ingstd ZYLOPIM (allopuinol) is xctd in th cs. Bcaus its apid oxidation toxipuinol and a nal claanc at appoximatly that glomula iltation at, ZYLOPIM (allopuinol) has a plasma hal-li about 1 t2 hous. Oxipuinol, howv, has a long plasma hal-li (appoximatly 15 hous) and thctiv xanthin oxidas inhibition is maintaind ov a 24-hou piod with singl daily doss ZYLOPIM (allopuinol) . Whas ZYLOPIM (allopuinol) is clad ssntially by glomula iltation, oxipuinol is absobd in th kidny tubuls in a mann simila tth absoption uic acid.
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