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Drugs in this class include actos pioglitazone , actoplus met pioglitazone and metformin , duetact pioglitazone and glimepride , avandia rosiglitazone , avandamet rosiglitazone and metformin , and avandaryl rosiglitazone and glimepride .
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Us mtomin in patints with hpatic impaimnt has bn associatd with som cass lactic acidosis; thapy is not commndd in patints with hpatic impaimnt.
Duing contolld clinical tials, on cas ovdos with pioglitazon was potd. A mal patint took 120 mg p day ou days, thn 180 mg p day svn days. Th patint dnid any clinical symptoms duing this piod.
Topiamat oth cabonic anhydas inhibitos (.g., zonisamid, actazolamid dichlophnamid) quntly caus a dcas in sum bicabonat and induc non-anion gap, hypchlomic mtabolic acidosis; concomitant us ths dugs with mtomin/pioglitazon combination may incas isk lactic acidosis; consid mqunt monitoing ths patints Dugs that a liminatd by nal tubula sction (.g., cationic dugs such as cimtidin) hav potntial intaction with mtomin by compting common nal tubula tanspot systms, and may incas accumulation mtomin and isk lactic acidosis; consid mqunt monitoing ths patints Alcohol is known tpotntiat th ct mtomin on lactat mtabolism; wan patints against xcssiv alcohol intak whil civing thapy I hypoglycmia occus in a patint coadministd pioglitazon/mtomin and an insulin sctagogu (.g., sulonylua), th dos insulin sctagogu should b ducd; i hypoglycmia occus in a patint coadministd and insulin, th dos insulin should b dcasd by 10% t25%; uth adjustmnts tinsulin dos should b individualizd basd on glycmic spons.
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