In addition, there has been evidence of oncogenic activity in rats in studies with a related antibiotic, oxytetracycline ie, adrenal and pituitary tumors .
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All tetracyclines are about equally active and typically have about the same broad spectrumwhich comprises both aerobic and anaerobic gram-positive and gram-negative bacteriamycoplasmasrickettsiaechlamydiaeand even some protozoaamebaeTetracyclines generally are the drug of choice to treat rickettsiae and mycoplasmaAmong the susceptible organisms is Wolbachiaa rickettsial-like intracellular endosymbiont of nematodesincluding Dirofilaria immitisStrains of Pseudomonas aeruginosaProteusSerratiaKlebsiellaand Trueperella spp frequently are resistantas are many pathogenic Escherichia coli isolatesEven though there is general cross-resistance among tetracyclinesdoxycycline and minocycline usually are more effective against staphylococci.<\/p>\n
Tetracycline passes into breast milk and may affect bone and tooth development in a nursing babyDo not take this medication without telling your doctor if you are breast-feeding a baby.<\/p>\n
Tetracyclines distribute rapidly and extensively in the bodyparticularly after parenteral administrationThey enter almost all tissues and body fluidshigh concentrations are found in the kidneysliverbilelungsspleenand boneLower concentrations are found in serosal fluidssynoviaCSFascitic fluidprostatic fluidand vitreous humorThe more lipid-soluble tetracyclinesdoxycycline and minocyclinereadily penetrate tissues such as the blood-brain barrierand CSF concentrations reach.<\/p>\n
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