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Metoclopramide should not be used in epileptics or patients receiving other drugs which are likely to cause extrapyramidal reactionssince the frequency and severity of seizures or extrapyramidal reactions may be increased.<\/p>\n
Safety and effectiveness in pediatric patients have not been establishedsee OVERDOSE<\/p>\n
Metoclopramide stimulates motility of the upper gastrointestinal tract without stimulating gastricbiliaryor pancreatic secretionsIts mode of action is unclearIt seems to sensitize tissues to the action of acetylcholineThe effect of metoclopramide on motility is not dependent on intact vagal innervationbut it can be abolished by anticholinergic drugs.<\/p>\n
Symptoms of overdosage may include drowsinessdisorientation and extrapyramidal reactionsAnticholinergic or antiparkinson drugs or antihistamines with anticholinergic properties may be helpful in controlling the extrapyramidal reactionsSymptoms are self-limiting and usually disappear within 24 hours.<\/p>\n
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