Norvasc 5 mg tablets amlodipine besylate equivalent to 5 mg of amlodipine per tablet are white, elongated octagon, flat-faced, beveled edged engraved with both norvasc and 5 on one side and plain on the other side and supplied as follows .
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Severe obstructive coronary diseaseSevere aortic stenosisCHFHepatic dysfunctionPregnancyNursing mothers.<\/p>\n
Limited available data from a published clinical lactation study reports that amlodipine is present in human milk at an estimated median relative infant dose of 4.2no adverse effects of amlodipine on breastfed infant reportedthere is no available information on effects of amlodipine on milk production.<\/p>\n
HemodynamicsFollowing administration of therapeutic doses to patients with hypertensionNorvasc produces vasodilation resulting in a reduction of supine and standing blood pressuresThese decreases in blood pressure are not accompanied by a significant change in heart rate or plasma catecholamine levels with chronic dosingAlthough the acute intravenous administration of amlodipine decreases arterial blood pressure and increases heart rate in hemodynamic studies of patients with chronic stable anginachronic oral administration of amlodipine in clinical trials did not lead to clinically significant changes in heart rate or blood pressures in normotensive patients with angina.<\/p>\n
Adjust dosage according to blood pressure goalsIn generalwait 7 to 14 days between titration stepsTitrate more rapidlyhoweverif clinically warrantedprovided the patient is assessed frequently.<\/p>\n
CommentsPatients who are small or fragile may be started on 2.5 mg orally once a dayThe dosage should be adjusted according to patient responseIn generaltitration should proceed over 7 to 14 daysIf clinically warrantedtitration may proceed more rapidlyprovided the patient is assessed frequently.<\/p>\n
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