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<\/a><\/center><\/p>\nInformation about Lamictal.<\/h2>\n<\/p>\n
This Medication Guide summarizes the most important information about LAMICTALIf you would like more informationtalk with your healthcare providerYou can ask your healthcare provider or pharmacist for information about LAMICTAL that is written for healthcare professionals.<\/p>\n
Gradual transient increasesinlamotrigine plasmalevels(approximate 2-fold increase)occurred duringtheweek of inactivehormone preparationpill-freeweekfor womennotalso takinga drug that increased the clearance of lamotriginecarbamazepinephenytoinphenobarbitalprimidoneor other drugs such as rifampin and the protease inhibitors lopinavir\/ritonavir and atazanavir\/ritonavir that induce lamotrigine glucuronidationsee DRUG INTERACTIONSThe increase in lamotrigine plasma levels will be greater if the dose of LAMICTAL is increased in the few days before or during the pill-free weekIncreases in lamotrigine plasma levels could result in dose-dependent adverse reactions.<\/p>\n
It is recommended that LAMICTAL not be restarted in patients who discontinued due to rash associated with prior treatment with lamotrigine unless the potential benefits clearly outweigh the risksIf the decision is made to restart a patient who has discontinued LAMICTALthe need to restart with the initial dosing recommendations should be assessedThe greater the interval of time since the previous dosethe greater consideration should be given to restarting with the initial dosing recommendationsIf a patient has discontinued lamotrigine for a period of more than 5 half-livesit is recommended that initial dosing recommendations and guidelines be followedThe half-life of lamotrigine is affected by other concomitant medicationssee CLINICAL PHARMACOLOGY<\/p>\n
Tell your healthcare provider about any side effect that bothers you or that does not go away.<\/p>\n
Aggressionexacerbation of Parkinsonian symptoms in patients with pre-existing Parkinson’s diseasetics.<\/p>\n
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