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Symptomatic postural hypotension occurred when SINEMET was added to the treatment of a patient receiving antihypertensive drugsThereforewhen therapy with SINEMET is starteddosage adjustment of the antihypertensive drug may be required.<\/p>\n
Studies show that peripheral dopa decarboxylase is saturated by carbidopa at approximately 70 to 100 mg a dayPatients receiving less than this amount of carbidopa are more likely to experience nausea and vomiting.<\/p>\n
There are no adequate or well-controlled studies in pregnant womenIt has been reported from individual cases that levodopa crosses the human placental barrierenters the fetusand is metabolizedCarbidopa concentrations in fetal tissue appeared to be minimalUse of SINEMET in women of childbearing potential requires that the anticipated benefits of the drug be weighed against possible hazards to mother and child.<\/p>\n
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